Hank marries the divorced Joan, who's the mother of teens Sebastian and Jessica. After living with his new family for years, Hank announces that he's getting a sex change operation. The family deserts Hank, with Jessica going her own way and Sebastian staying with his mom. But Joan becomes an alcoholic, so Sebastian moves back in with Hank — now Henrietta — who turns out to be far more supportive than anyone else.
Adrian Grenier
Sebastian Cole
Clark Gregg
Hank / Henrietta
Aleksa Palladino
Mary
Margaret Colin
Joan Cole
John Shea
Hartley Cole
Marni Lustig
Jessica Cole
Joan Copeland
Grandmother Cole
Gabriel Macht
Troy
Herbert Russell
Wayne
Peter McRobbie
Principal
Merritt Wever
Susan
Marisol Padilla Sánchez
Woman In Dessert
Rory Cochrane
Chinatown
Levon Helm
Juvie Bob
Famke Janssen
Fiona
Nicole Ari Parker
Nurse Jenny
Graeme Malcolm
John
Miguel Nájera
Man In Dessert
Jane Jensen
Nightclub Girl
Joe Lisi
Concrete Guy
Tod Williams
Liquor Store Guy