After dominating the boxing world, Adonis Creed has thrived in his career and family life. When a childhood friend and former boxing prodigy, Damian Anderson, resurfaces after serving a long sentence in prison, he is eager to prove that he deserves his shot in the ring. The face-off between former friends is more than just a fight. To settle the score, Adonis must put his future on the line to battle Damian — a fighter with nothing to lose.
In the aftermath of Cassius Clay's defeat of Sonny Liston in 1964, the boxer meets with Malcolm X, Sam Cooke and Jim Brown to change the course of history in the segregated South.