Luì is about to receive his diploma as a scientist until Mr. S and Perfidia will try to undermine the Me against You.
A beautiful school is about to reopen after many years and Luì and Sofì (Me against You) are the special guests of the inauguration party, their friend Pongo awaits them there. The school, however, could hide a mystery and, once again, the Me against You will have to face the evil Mr. S with courage and try to sabotage his evil plans in the name of friendship. In the school, for the first time, Luì and Sofì could learn an important secret about their past. A new “magical” adventure in the cinema for Luì and Sofì, in a world of magic, with lots of surprises and fun for their little fans and all families.
Milan, Nowadays: Fernando, son of Ugo Piazza, is a brilliant criminal defense lawyer whose mother, Nelly, has done everything in her power to raise him different from his father, a deplorable gangster.
The past interlaces with the present: the discovery of a mysterious yellowed photograph depicting a little girl will lead Christian and Jewish students to search for the truth. They undertake a journey through the memory of a painful past that is hard to forget, such as the memory of the raid on the Jewish ghetto of Rome.