Ching Ka-ying and Koo Ching-king are lovers and Chinese medicine graduates. Ching-king chooses to continue with his medical studies, causing the couple to end their relationship. Ten years later, the duo run into each other again. Ka-ying has become a public Chinese medicine center service supervisor. Although Ching-king is a Doctor of Chinese Medicine, he works under Ka-ying as her subordinate as he could only apply for the position of CM trainee practitioner. Even though the duo often quarrel due to their different beliefs, they are benevolent medical practitioners hoping to use their medical knowledge and experience to help patients. Despite the fact that there are many restrictions placed on CM practitioners in the health care system, they jointly oversee a contingent of novice CM practitioners, including Lo Yuen-chi, Yuen Si-si, Tong Siu-kwong and Pang Ching-mong. Together they create what they regard as the ideal Chinese medicine center and boldly go down the road to benevolence.
Thirty years ago, hardened criminal Yip Siu-tin is arrested for armed robbery and sentenced to prison. Siu-tin’s daughter, who has handled the loot, changes her name to Cheung Sum-yuet and starts a new life. She also gets married to yacht company boss Yen Ho-yin. Meanwhile, Chong Chi-kiu is a kid left behind by an accomplice who has died because of the robbery. Kind-hearted Tang Sing-him becomes his foster parent. A traffic accident causes Chi-kiu and Sum-yuet to run into each other again. But this accident somehow has something to do with Siu-tin, who is just released from prison. Sum-yuet can no longer avoid Siu-tin, who is a nightmare to her. Her marriage also has certain issues. Police officer Yeung Yan-hiu intervenes by launching an investigation, and she keeps going after Siu-tin and Chi-kiu. Unresolved grudges for thirty years are again put on the front burner. Everyone implicated in a robbery of yesteryear is drawn into this mess.
Sequel to 77 Heartbreaks, 77 Heartwarmings, sees the return of Charlene Choi as Eva, and Chau Pak-ho as her ex-boyfriend Adam. Although it has been a year since their relationship ended, Adam is still very fond of Eva and hopes to win her back. He comes across an app that teaches him what to do to reignite the passion in Eva. While Adam tries the tips mentioned in the app and gradually bridges the gap between them, Eva meets Thai star Marvel (Mario Maurer), who also vies for Eva’s love.