"Golpe de Suerte" tells the lives of three families from different social classes. First there are the Pérez Flores, who live in Neza and are made up of Ignacio, Julia and their children Ronaldo and Wendy. The second family is made up of Miranda Ortiz and her little son Diego; They live in the Roma neighborhood in the house of César Traven, a generous elderly antiques dealer. And finally there are Brenda Uriarte, her brother Tony, her stepmother Constanza and her stepsister Sabrina, an upper middle class family. Each of these families will experience a radical change in their lives the day they win two hundred million pesos.
Adrián is a gambler who, after having an incident in his town, hides in the city as a teacher, and cannot resist the daring provocations of his female students.
A student, seeing the feeling he has with the girls at his school and seeing the fame that he created as a gigolo, decides to start prostitution on the internet. This leads him to date all kinds of women, especially those who are still virgins.
Oscar is a handsome boy who, in a night out with his friend, meets Bárbara, a Venezuelan girl with whom he falls in love. He does not imagine that Elvis, Barbara's ex-boyfriend, will come to collect a debt that he had pending with her.
Adrián is a handsome and lucky trainer of high society ladies, who divides his time between training ladies, seducing them and scamming them until an old account catches up with him at the least expected moment.