Go! Princess PreCure is set in a boarding junior high school, named Noble Academy. The protagonist Haruka Haruno is a 13-year-old first-year student. Her big dream is to be a princess someday because she admired a princess in the picture book she has kept since her childhood. One day, she transforms into Cure Flora with the "Dress Up Key" which Prince Kanata of Hope Kingdom gave her as a good luck charm when she was little. Then she also finds other Pretty Cure girls in her school, 14-year-old Minami Kaidou as Cure Mermaid and 13-year-old Kirara Amanogawa as Cure Twinkle. As the Princess Pretty Cure team, with two fairies Pafu and Aroma, they fight against the dark witch Dyspear, who hates all the dreams in the world and wants to turn them to despair.
Shouta is sent back in time to his elementary school days via a mysterious school pool. He sees Konomi, a girl who would eventually become a nationally popular actress, and other cute girls when they were innocent and defenseless.
One night, a boy named Takuto washes up on shore swimming from the mainland. He later enrolls in Southern Cross High School as a freshman and makes new friends. However, beneath the school is a group of mysterious giants called Cybodies, which can be controlled by humans in an alternate dimension known as Zero Time. Takuto, The "Galactic Pretty Boy", finds himself dragged into opposition with the "Glittering Crux Brigade".
Satsuki Kakeru lost his sister by suicide and has been living a dull life ever since then. One day, he is transported into a bizarre world "Red Night" along with his friend Minase Yuka. In order to survive and escape from Red Night, he fights against Dark Spirits (Ralva) and Black Nights.