Mad scientist Prospero runs away with his blind daughter Miranda to Tromaville, hiding from evil pharmaceutical execs, including his own sister Antoinette who ruined his career after he found the cure against opioid addiction. With the help of a handicapped crack-whore, he releases a massive amount of laxative to whales, while his enemies are on a cruise ship to North Korea. A humongous shitstorm washes the boat away and brings them to Tromaville, where Prospero can now fully realize his ultimate vengeance.
Beta signs up for a standup comedy competition despite having never been on stage before. She asks Húgó, the winner of the same competition 10 years earlier for help with her comedy. This awakens a desire for the past in Húgó, while Beta tries to overcome her insecurities.