Duetto takes place in 1965 and tells the story of 18-year-old Cora, a Brazilian from an Italian family who, after losing her dad in a tragic car accident, goes with her grandmother Lucia to Puglia, Italy, where her ancestral homestead still stands. Lucia, aiming to sell an old family land lot, reencounters her sister Sofia and her husband Gino, whom she hasn't spoken to in 40 years.
Lucas and Bebel decide to get married and have no idea that religion will be a reason for discord in families. While the bride's father wants to strengthen Jewish traditions, Luke's mother wants her son to take Umbanda traditions to his future family.
Young, intense and authentic, Dani just wants a normal life. However, since she was a child, she has been misaligned with her world.