The story of Hugh Knight, a rising heart surgeon who is gifted, charming and infallible. He is a hedonist who, due to his sheer talent, believes he can live outside the rules. His "work hard, play harder" philosophy is about to come back and bite him.
Running the remote Hope Island Clinic, Sam Stewart is an accomplished doctor, who with her team, looks after the residents of all the neighbouring islands, as well as the holidaymakers and thrill seekers who visit the area. Not only a GP, Sam is a single mother with a free spirit and a determination – who has an unusual hobby: venom.