Fraternal twins Nikki and Nora are forced back into each other's lives when they inherit a detective agency. As they solve a murder, they realize their differences may be their greatest advantage.
When Toby loses her job and starts a nonprofit to rehabilitate abused rescue dogs at the local prison, she hatches a plan to break her lover out of prison by smuggling him out in one of the dog crates, sparking a federal manhunt.
A prophetic young dishwasher with brain-damage and a homeless prostitute are brought together through obscene circumstances and embark on a perverse journey through the gutter.