Theater actress Lillian Cooper's son dies mysteriously. When the investigating officer rules the cause of death an accidental overdose, Lillian conducts her own investigation which leads her to an unlikely alliance with her son's former drug dealer. On her quest for answers, Lillian hallucinates some of the iconic characters she's played on stage which serve as her inner voice, urging her to avenge her son's death.
While humorous, sarcastic and sometimes harsh, Dominique the Dame brings to the forefront America's contemporary views on race, sex, drugs, religion and technology through her listeners who call into her show "Real Talk." The radio program takes on a greater meaning when Dame mobilizes her listeners in a race against time to save the life of a pregnant teenager.