In this new installment, Mister Twister faces a major challenge as he has to stand on his own. While continuing to inspire his students with creative teaching methods, he deals with changes both at school and in his personal life. The strict principal keeps him on his toes, and his students never fail to surprise him in their own unique ways. Filled with humor and heartwarming moments, the film shows how Mister Twister, despite the obstacles, always manages to bring out the best in his class.
12-year-old Jackie has made Amsterdam's Rijksmuseum, where her mom works, her second home. While wandering around after hours, Oopjen from Rembrandt's famous painting suddenly comes to life. It seems she is looking for her long lost sister. Jackie is used to solving other people's problems and decides to take Oopjen home, so they can go look for her sister. For the woman from the Golden Age, this modern world, its customs and appliances are a great adventure. And Jackie, who doesn't really have any friends at school, finally gains a true BFF.