Minerva Henerala is a softhearted and dedicated high school teacher who loves her students despite their naughtiness inside the classroom. Years ago, she lost her mother and sister to a tragic archaeological accident. At the same site, she had a close encounter with mythical glowing winged-creatures and shapeshifters called Tamawo, and she grew up believing that they exist among humans. As the years go by, the Tamawos abduct children to feed on their youthful energy. Now it is up to Minerva's alter-ego, Super Ma'am, to become a Tamawo hunter and save the human world.
The story revolves around Juan dela Costa and Happy. The two meet each other when Juan rescues Happy from a thief. Their romance leads to a wedding. Their relationship with their families is opposed, and the couple can't have a child on their own, so they decide to adopt one instead.
Kim Domingo, is a Filipino actress, model, singer, Internet personality, and television presenter. She is well known for playing the leading antagonist in Juan Happy Love Story, Tsuperhero and Super Ma'am. She is currently a GMA Network contract artist.