Hellboy and a rookie BPRD agent get stranded in 1950s rural Appalachia. There, they discover a small community haunted by witches, led by a local devil with a troubling connection to Hellboy's past: the Crooked Man.
A close-knit group of rebellious London teenagers are on a getaway in Rotterdam. But after the estranged father of Tara is discovered dead, they find themselves on the run across Europe with three kilos of heroin and a host of deadly criminals snapping at their heels.