A government program poisons millions. An immune grandfather-granddaughter duo survive, hunted by ruthless scalpers and an official determined to save his son, leading to a fight for survival amidst the chaos.
With the help of two mysterious hunters, Detective Launa Chanee tracks down a mythical beast that is leaving a trail of mangled bodies. As they draw closer they begin to question, is this a beast of myth and legend, or something entirely new?
Michael manages to free himself from Laurie Strode's trap to resume his ritual bloodbath. As she fights for her life from injuries from their last encounter, she inspires her daughter Karen, her granddaughter Allyson, and all of Haddonfield to rise up against the unstoppable monster.