Yui Saizo is a single, 29 year old woman and works in the crime laboratory at the Takanashi Police Station as a forensics examiner. She does her job well, due to her excellent memory and analytical mind. She prioritizes efficiency at her work. She also eschews the old-fashioned and traditional ways at the police station, like, working overtime or being liked by colleagues. She does have two close female colleagues at the police station. They are Masumi Kira and Iori Motoyama. Masumi Kira works as a physician in the medical office and Iori Motoyama works in the traffic department. Every Friday night, these 3 women gather at an izakaya pub and chat about everything including work and relationships. One Friday night, during the course of their normal conversation, they talk about a case that detectives at the police station are having trouble solving. Since then, they talk about difficult cases and try to solve the cases using their respective talents.
When an estranged friend resurfaces after 12 years, a prosecutor starts connecting disjointed events to unveil the truth behind her father's tragic death.
A proud young calligrapher is punished for punching a critic by being sent to a faraway island in the east coast of Japan. But as he meets and lives with the island's friendly people, his attitude begins to improve.
Yoshino Michi is 32 years old. She's been married for five years, but hasn't had sex for the last two. It's not as if she doesn't get along with her husband, it's just that the sex part is lacking. It was a bit unexpected, but one night when she when drinking with her colleague, Niina Makoto, she wound up confessing that her marriage had turned sexless. And then, a shocked Niina responded "My marriage is sexless, too," and smiled with a lonely look in his eyes.
Asahi is a 23-year-old boy who attracts everyone around him with his innocent smile, words and talent. Chatani Kashiko is a 35-year-old working for a small advertising agency and is someone who has low self-esteem. Meanwhile, Sato Wataru is an expressive woman and works as a backstage actress in a small theatre company run by her boyfriend, who sometimes uses her as a ghostwriter. Kashiko and Wataru used to be best friends in high school and unexpectedly reunite through Asahi.
Kohiruimaki Yuichi is a police officer who established the "Science Crime Countermeasures Office", a department that specializes in issues related to cutting-edge science and technology. He welcomes the genius scientist Mogami Yukiko as an advisor and she is in charge of investigating cases related to cutting-edge science. The crimes entrusted to the Science Crime Countermeasures Office are crimes that the legal system and police organization cannot keep up with. The two will unravel the science itself hidden behind the cases and not just the so-called forensic investigation. Hasebe Tsutomu is a detective who is not familiar with science but has a long experience in the field in the former Investigation Division.
6 people considered "losers" in life begin to live together in a mysterious share house. Abiko Satoshi is a high school teacher. His life went by smoothly, until a case changed his life. Oba Sakura is the chief editor of a fashion magazine. She is finalizing a divorce with her husband. Hata Manta is a retail employee involved with product demonstrations. He considers himself an entertainer, but he is not popular at all. Mochizuki Mai moved to Tokyo from Hakata. She works at a hostess bar. Kurumizawa Midori is a civil servant. She is diligent at her job, but she is in mired in debt due to her gambling addiction. Ikegami Ryuji worked at an advertising agency. He did his job very well, but he was dismissed from his job.