This medical drama tells the story of a group of neurosurgeons with different personalities, facing patients with various intractable diseases and complicated operations, conscientiously saving lives in their respective positions. The two deputy chief physicians of neurosurgery, one is a "Lone Ranger" and the other is a "Surgery Frenzy". The two have different styles, but they will not have a better life with anyone. "Lone Ranger" Fan Xun (nickname Gu Xiong), the first quick knife in neurosurgery, but he is indifferent, advocating surgery is not the only way to solve the disease. "Surgery mad" Dai Yi Shan (nickname Doctor Shan), returning from overseas, holds the position of deputy director of neurosurgery at a young age, advocating that technology will replace labor, and advanced technology can solve all diseases.
During the 1937 Japanese invasion, three half-brothers from the Luo family reunite and, led by the eldest, Gu Shimin, join the resistance. When one brother uncovers a Japanese plan for a deadly chemical weapon, the brothers unite to infiltrate the enemy and destroy the factory, playing a key role in the war effort.