Me and Moffun is about the cryptid hunter, Panpy. He goes out searching for a legendary yeti in the snowy mountains. There he meets the yeti, Moffun, who takes him to the Mofu Village. The story revolves around Panpy's adventures with Moffun in the village.
Filled with rage against spirits known as tsukumogami, Kunato Hyoma is sent to live with Nagatsuki Botan to help him see a different side. Though both are part of a clan that return the spirits back to their world with divine powers, their experiences with the otherworldly vessels are vastly different. Kunato, robbed of a loved one, and Nagatsuki, saved by them. Can she get through to him?