Unlucky assassin Ladybug is determined to do his job peacefully after one too many gigs gone off the rails. Fate, however, may have other plans, as Ladybug's latest mission puts him on a collision course with lethal adversaries from around the globe—all with connected, yet conflicting, objectives—on the world's fastest train.
Hiding out with his son Taylor on the Mexican coast, Nero hopes to put his violent Special Forces career behind him. But after Nero’s home is attacked and Taylor is abducted, the mysterious Mzamo orders Nero to slaughter the members of three rival crime syndicates. If he fails, Taylor will die. Now, with bullets flying and bodies dropping as Nero completes his mission, he races to find Mzamo’s hideout and seek revenge.