Tonino Esposito is the son of the fearsome Camorra boss of Rione Sanità, Naples. Unlike him, however, Tonino is clumsy and utterly innocuous—a decent person at heart—and so when his father dies he's passed over in matters of succession. His pride wounded, he doesn't resign himself and tries to be his own boss, only managing to make a fool of himself. When he finds out that his daughter is dating to the son of the judge prosecuting the new boss, Tonino sees the opportunity to prove himself in front of his family and all of Naples.
When his girlfriend Giorgia leaves him for his boss, journalist Giulio suddenly finds himself without a woman and with no job. Determined to win back his ex, he attends Valeria's classes, who teaches single men the art of seduction, convinced that relationships between people are motivated by simple biological stimuli.