Marcus and Mike are forced to confront new threats, career changes, and midlife crises as they join the newly created elite team AMMO of the Miami police department to take down the ruthless Armando Armas, the vicious leader of a Miami drug cartel.
In her pursuit to synthesize a breakthrough stem-cell based treatment for lymphatic cancer, a clinical researcher takes up her assistant's offer to go rogue, and finish their last run of experiments clandestinely.