When Reggie is abandoned on the mean city streets by his lowlife owner, Doug, Reggie is certain that his beloved owner would never leave him on purpose. But once Reggie falls in with Bug, a fast-talking, foul-mouthed stray who loves his freedom and believes that owners are for suckers, Reggie finally realizes he was in a toxic relationship and begins to see Doug for the heartless sleazeball that he is.
Supervillains Harley Quinn, Bloodsport, Peacemaker and a collection of nutty cons at Belle Reve prison join the super-secret, super-shady Task Force X as they are dropped off at the remote, enemy-infused island of Corto Maltese.