Tsubomi Hanasaki is a girl in the second grade of middle school who likes flowers and plants. One day she experiences a weird dream. In that dream, a large blooming tree appears. Suddenly, it loses all of its flowers and 2 fairies appear. A few days later after Tsubomi has transferred to Myoudou Academy, suddenly the fairies from the dream appear before her and plead to Tsubomi to become the legendary warrior Pretty Cure, and protect the Heart Tree. However, Tsubomi declines as she doesn't think that she would be able to do that. However, a mysterious enemy suddenly strikes and steals the Heart Flower of her classmate, Erika Kurumi. Now she doesn't have a choice. To retrieve Erika's Heart Flower, she has to transform into a Pretty Cure and fight. Working up the courage, Tsubomi turns into Cure Blossom and a new chapter of Pretty Cure begins!
Venus Versus Virus revolves around the life of a young girl named Sumire Takahana who has had the power to see ghosts since she was a small child, though no one believes her. One night while running to her dorm building to make curfew, a broach flies out of no where and she pricks her finger on it and sees a demon. Suddenly, another girl clad in gothic lolita clothing arrives bearing a huge gun and kills the demon. Once the ordeal is overwith, the girl gives Sumire a flier for a local clothing store, Venus Vanguard. When Sumire comes to the store, the girl, whose name is Lucia Nabashi, she explains to her that because she pricked her finger on Lucia's broach, Sumire now has the power to see demons as well as ghosts. Additionally, Lucia now wants Sumire to help her rid the world of these demons called Virus that threaten to consume all of humanity.