A group of friends seal themselves inside a secluded Cape Cod vacation home after a mysterious orange fog leaks from an old nearby factory. Once trapped, they quickly learn there is no escape.
Over a long weekend, John & Marlena travel to Zurich, Ben & Ciara have a romantic getaway in New Orleans, Chad visits some old friends in Phoenix, and Abe, Paulina, Lani, and Eli vacation in Miami. All find themselves embroiled in a mystery involving stolen jewels which, in the wrong hands, could cause dire consequences for Salem.