When Gu Yunzheng, an associate professor of neurosurgery, goes on a medical aid mission in Lacaya, he meets Su Wei'an, a "deserter" who has abandoned her medical career to become a businessperson. From bickering all the time to falling in love with each other, he gradually discovers that all her abnormal behavior is caused by a genetic disease called Huntington's disease. The love for his beloved one makes him empathize with the sadness and despair of this incurable disease faced by 30,000 patients and their families across the country. Finally, Gu Yunzheng decides to give up his promising career and devote his life to the research of curing this rare disease, fighting alongside his lover to carve light out of the darkness.
Legend has it that the Han and Di families together established the Great Jing. However, ten years ago, the Di family was convicted of treason, leaving behind only one orphaned girl imprisoned in Daishan. Ten years later, Han Ye, the determined crown prince who aimed to rescue the Di family's lone survivor, unexpectedly crossed paths with a spirited and enchanting female pirate who claimed that she would marry none other than him. She called herself Ren Anle and brought with her a fleet of thirty thousand soldiers, arriving in the capital city to seek the prince's hand in marriage. Throughout the process of relentlessly pursuing Han Ye, Ren Anle demonstrated remarkable wit and intelligence. As their shared values and national aspirations aligned, Han Ye couldn't help but develop affection for Ren Anle.
The story took place in two parallel universes named Yuan and Yi, where people shared the same life and death. Nian Yangxiao, came from the Yuan World to save his true love Kong Linghui, crossed the border to the Yi World in search of the killer who assassinated his love. In the Yi World, however, he and Kong Linghui were enemies. Kong Linghui tried everything to kill him. At the same time, the mysterious girl Yong'er, the romantic street gangster, the cold-faced police officer Nuo Dun and others appeared one after another, each accompanied with a complex case. The involvement of Nian Yangxiao made the cases more complicated and confusing. A suspenseful, thrilling, blood-burning and fantastic adventure in different time and space was launched in "A Portrait of Jianghu: Double Life".