A pampered Beverly Hills chihuahua named Chloe who, while on vacation in Mexico with her owner Viv's niece, Rachel, gets lost and must rely on her friends to help her get back home before she is caught by a dognapper who wants to ransom her.
Drew Barrymore
Chloe (voice)
Piper Perabo
Rachel Ashe Lynn
Andy García
Delgado (voice)
George Lopez
Papi (voice)
Paul Rodríguez
Chico (voice)
Plácido Domingo
Monte (voice)
Edward James Olmos
Diablo (voice)
Loretta Devine
Delta (voice)
Jamie Lee Curtis
Aunt Viv
Luis Guzmán
Chucho (voice)
Eddie 'Piolin' Sotelo
Rafa (voice)
Grey DeLisle
Mother Dog (voice)
Manolo Cardona
Sam Cortez
Leslie Mann
Bimini (uncredited)
Cheech Marin
Manuel (voice)
Michael Urie
Sebastian (voice)
José María Yázpik
Vasquez
Maury Sterling
Rafferty
Jesús Ochoa
Officer Ramirez
Eugenio Derbez
Store Owner
Omar Leyva
Ranger
Ali Hillis
Angela
Marguerite Moreau
Blair
Nick Zano
Bryan
Gina Gallego
Shelter Director
Alberto Reyes
Bellman
Brandon Keener
Waiter
Sal Lopez
Ring Announcer
Jack Plotnick
Dog Nanny
James P. Bennett
Bull Fighter (uncredited)
Mary Paz Mata
Shaman Lady
Tomihuatzi Xelhuantzi
Museum Security Guard
Mayra Sérbulo
Poor Woman
Fernando Manzano
Desk Sergeant
