In 1859, families discover the lure of the Old West as they settle in territories from Wyoming to Kansas. Meanwhile, a gruff cowboy soon finds himself on the run with a prostitute and a young boy after killing a fellow gunman.
An aristocratic Englishwoman, Lady Cornelia Locke, arrives into the new and wild landscape of the American West to wreak revenge on the man she sees as responsible for the death of her son.
In the 1870s, a young Harvard dropout seeks his destiny out West by tying his fate to a team of buffalo hunters led by a man named Miller. Together, they embark on a harrowing journey risking life and sanity.