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Bighead and his henchmen blast Ace and Gary with a flesh ray, transforming them from animated characters to live-action ones, in which they are portrayed by Jon Hamm and Jimmy Fallon, respectively. The gun malfunctions and "unanimates" everyone, with Ed Helms playing Half-Scary, a Two-Face-like henchman, Fred Armisen as Lizardo, Stephen Colbert as Dr. Brainio, and Steve Carell as Bighead.
Stephen Colbert
Ace / Dr. Brainio (voice)
Steve Carell
Gary / Police Commissioner (voice)
Tracy Morgan
Mr. T. (archive sound)
Bill Hader
Flame Eye / Flatside (voice)
Bill Chott
Announcer / Chief of Police (voice)
Robert Smigel
Bighead / Beetles of Zolaro / Lizardo / Half-Scary (voice)
Ana Gasteyer
Queen Serena (voice)