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The Powerpuff Girls must stop Fuzzy Lumkins from turning the city into meat.
Cathy Cavadini
Blossom (voice)
Tara Strong
Bubbles (voice)
E. G. Daily
Buttercup (voice)
Tom Kenny
Mayor / Snake / Lil' Arturo / Narrator (voice)
Tom Kane
Professor Utonium / Him / Talking Dog (voice)
Roger L. Jackson
Mojo Jojo (voice)
Jennifer Martin
Ms. Sara Bellum (voice)
Jennifer Hale
Ms. Keane / Princess Morbucks / Sedusa (voice)
Jim Cummings
Fuzzy Lumpkins (voice)
Jeff Bennett
Ace / Grubber / Big Billy (voice)
Chuck McCann
The Amoeba Boys (voice)