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The Powerpuff Girls try to stop the villains of Townsville from obtaining the Key to the World, which actually gives its possessor the right to rule the world.
Cathy Cavadini
Blossom (voice)
Tara Strong
Bubbles (voice)
E. G. Daily
Buttercup (voice)
Tom Kenny
Mayor / Snake / Lil' Arturo / Narrator (voice)
Tom Kane
Professor Utonium / Him / Talking Dog (voice)
Roger L. Jackson
Mojo Jojo (voice)
Jennifer Martin
Ms. Sara Bellum (voice)
Jennifer Hale
Ms. Keane / Princess Morbucks / Sedusa (voice)
Jim Cummings
Fuzzy Lumpkins (voice)
Jeff Bennett
Ace / Grubber / Big Billy (voice)
Chuck McCann
The Amoeba Boys (voice)